Collagen Wound Dressing

Venous Stasis Ulcer Right Leg (Case 26)

Venous Stasis Ulcer Full Thickness-right Leg (Case 27)

Venous Stasis Ulcer Right Foot (Case 28)

Venous Stasis Ulcer Sacro-Coccyx Region (Case 29)

Stage IV Pressure Ulcer Sacro-Coccyx Region (Case 30)

Stage IV Pressure Ulcer Sacro-Coccyx Region (Case 31)

Stage IV Pressure Ulcer Sacro-Coccyx Region (Case 32)

Stage IV Pressure Ulcer Sacro-Coccyx Region (Case 33)

Stage IV Pressure Ulcer Right Foot Heel (Case 34)

Surgical Wound Dehiscence Abdomen (Case 35)

Findings

The average reduction in wound surface area achieved was 1.4cm² per week.
The average reduction in depth of the wound was 0.1cm per week.

Conclusion

In managing chronic wounds, collagen dressings have shown to be an effective modality. Our evidence based clinical study shows that when a Bovine Type I collagen is utilized as a treatment for a full thickness wound; approximately 10% reduction in wound surface area and 9.5% in the depth of the wound may be achieved. Though our study is limited by small sample size but clinical data is consistent with the positive effects of Type I collagen in the management of Chronic wounds.

References

1. Mathew-Steiner SS, Roy S, Sen CK. Collagen in Wound Healing. Bioengineering (Basel). 2021 May 11;8(5):63. doi:10.3390/bioengineering8050063. PMID: 34064689; PMCID: PMC8151502.

2. De Francesco F, De Francesco M, Riccio M. Safety and Efficacy of Collagen-Based Biological Dressings in the Management of Chronic Superficial Skin Wounds in Non-Complex Trauma: A Post-Marketing Surveillance Study. Trauma Care. 2021; 1(3):195-205. https://doi.org/10.3390/traumacare1030017

3. Sen, C.K.; Gordillo, G.M.; Roy, S.; Kirsner, R.; Lambert, L.; Hunt, T.K.; Gottrup, F.; Gurtner, G.C.; Longaker, M.T. Human skin wounds: A major and snow balling threat to public health and the economy. Wound Repair Regen. 2009, 17, 763–771

4. Zhang M-X, Zhao W-Y, Fang Q-Q, et al. Effects of chitosan-collagen dressing on wound healing in vitro and in vivo assays. Journal of Applied Biomaterials & Functional Materials. 2021;19.

5. Li Zhang, Simei Wang, Meihua Tan, Hongwei Zhou, Ying Tang, Yan Zou, “Efficacy of Oxidized Regenerated Cellulose/Collagen Dressing for Management of Skin Wounds: A Systematic Review and Meta-Analysis”, Evidence-Based Complementary and Alternative Medicine, vol. 2021, Article ID 1058671, 10 pages, 2021. https://doi.org/10.1155/2021/1058671

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